Revealing mistake: In the chase scene about an hour into the movie, Robert Loggia is shown entering the Liberty Tunnel, driving on a wet road. Note the vaulted round ceiling of the tunnel. Next, we see a series of shots of him in the tunnel, and then a shot of the sun rising over Pittsburgh as he is about to leave the tunnel. Here is the problem - the sunrise shot is taken from the Fort Pitt tunnel on a different day. Note the dry road, the barriers to the driver's left at the tunnel exit and the Fort Pitt bridge straight ahead. There is no place for the driver to make a left turn out of this tunnel. Also note that the POV is from the left lane. All the Liberty Tunnel shots show Loggia in the right lane. The next shot shows Loggia exiting the Liberty Tunnel and making a left turn from the right lane, causing a pile-up.
Trivia: As Loggia and his henchmen are about to enter the strip club, note the movie marquee in the background with the title "See You Next Wednesday." This fictional movie is director John Landis' first attempted screenplay, and appears somewhere in most of his films. Source: http://en.wikipedia.org/wiki/See_You_Next_Wednesday.