Audio problem: At one point in the game Carlos loses his accent and speaks without the accent throughout the rest of the game.
Other mistake: The hospital elevator that operates via voice decoding system - so it can only be opened by the doctor (s) - is absolutely out of any sense. It would make visitors, nurses, maintenance workers, emergency services (police, firefighters), etc. to be unable to access or leave certain areas of the building without constant doctoral escort. Even there are secretly operating Umbrella labs in the facility, this method of keeping unwanted personnel outside is illogically exaggerated.