Ryan (George Clooney) leaves abruptly one of his presentations and goes to see Alex. He visits Alex (Vera Farmiga) at her house and realizes that she's married. Some time later they talk and Alex tells Ryan that she considers him an escape from her married life and that she was never interested in a serious relationship. Ryan achieves his 10 million frequent flier miles but he doesn't feel happy at all. Natalie (Anna Kendrick) quits her job because one of the people she fired (earlier in the film) kills herself. Ryan gives part of his frequent flier miles to his sister and her husband because they couldn't afford a honeymoon. He writes a letter of recommendation for Natalie when she goes to San Francisco looking for a new job and she gets hired. The film ends with Ryan taking a flight to any destination (following what Natalie said earlier in the film). The last scene is a view of the clouds and Ryan says: "The stars will wheel forth from their daytime hiding places and one of those lights, slightly brighter than the rest, will be my wingtip passing over..."
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