Continuity mistake: When the Wild Hogs first go to the Delfuego Bar, it is a bright sunny day and the ground is completely dry. When Woody had to go back and recover Dudley's bike the ground is completely wet, but when Woody is riding Dudley's bike back to the other Wild Hogs, the ground is again dry.
Continuity mistake: When the guys are being hit by bugs, you see Woody drive past everyone, when he gets hit by the bird you see him passing everyone again.
Continuity mistake: When Dudley is thrown through the window of the diner, the window is shattered. In the next scene, the window is back without being broken, then in the next scene, it is broken again.
Factual error: At the 28 minute mark, the Wild Hogs cross the Taos River Gorge Bridge in Taos, New Mexico. Shortly after the scene with the skinny dipping, they drive down the road and at the 34 minute mark, the sign on the right says, 'Missouri State Lane.' I never knew Missouri was inside the state of New Mexico.
Factual error: Tim Allen and Martin Lawrence's wives arrive to confront them in Madrid, NM from OH around breakfast time in Madrid. They only learned where the guys were the night before, after dark, which in summer is probably after 8 PM. There is no way to drive from OH to Madrid in the time shown in the movie. Assuming they left immediately, and even considering speeding, they would have to average over 83 mph, with no stopping for gas or food, passing through major cities with traffic, and somehow evade state troopers the whole way, to arrive by mid to late afternoon in Madrid. To arrive around breakfast time, even around 10 AM, they would have to average almost 100 mph. Since the action takes place around breakfast time-the guys haven't even had their breakfast yet, and were seen debating whether to eat in Madrid or down the road-it is inconceivable how the ladies can arrive from over 1300 miles away, shortly after the biker gang arrived, when the gang were only a couple hours ride away. The mini van they are driving was the family van, so they didn't fly out and rent one at the nearest large airport, which would be Albuquerque, 50 miles away. Even if the ladies were as angry as depicted, it's impossible to drive that far without needing to gas up, and speeding would mean more frequent fuel stops.
Plot hole: When they are swimming and before the family shows up, the Wild Hogs throw all their clothes on to the side of the pool. When the family gets in and they get caught, the mom seems to see the clothes from across the pool but she is looking the opposite way of where the clothes should be.
Audio problem: When Damien Blade shows up at the end, he shows up on a motorcycle close to the crowd, right on the main road, yet there's no sounds of a motorcycle pulling up before hand. They would definitely have noticed him pull up and hear his motorcycle coming in way before he stepped off the bike and the crowd parted way.