Continuity mistake: In the pot shack scene Dax Shepard is holding the package of pot to his side, you see him slowly move it behind his back to hide it from the two hillbillies. In the next scene, after they flash back from the hillbillies, it's back at his side and he's once again slowly moving it to his back. Shepard, and the other cast, admit this is a mistake in the commentary. (00:42:20)
Other mistake: As 2 of the trio are in the store just before meeting the cop, one is on his cell phone. In one of the frontal shots of him talking, you can see the other two approach from behind then suddenly back up quickly. As said on the commentary, they didn't get a cue to go, and then realized they were wrong and backed up. (00:19:05)
Continuity mistake: Near the end, when Tom, Jerry, and Dan are about to be shot by the two hillbillies and the cop, there is a brief scene that shows all three guns being loaded from a side view. The gun closest to the camera is a handgun. When the camera zooms out, all three men have rifles. There is no handgun to be seen. (01:27:40)
Visible crew/equipment: In the shot of the three guys urinating, look at their backs. The one on the far left has a visible battery pack, which "looks like a lunch box" as said on the commentary. (00:22:45)
Continuity mistake: After the canoe overturns and one of the trio gets on and surfs on it, watch his blue shirt as it is wet, to dry, to wet, throughout the rest of the river run. (00:36:25)
Continuity mistake: After the two hillbillies return to their burned-out field of pot, you can see them stepping on lots of burned tree branches thicker and longer than anything that could have come from one of the plants. What are tree branches doing in a clearing? (00:47:20)
Continuity mistake: When Jerry is using the radio, the cord has a little bit of cloth near the mic end. Then when Jerry gives the mic to Flower, to give the location, the whole cord is covered in cloth. (00:57:25)
Factual error: During their first night's camping, they encounter a bear..a Kodiak bear. Unfortunately, the only bears found in Oregon's Cascade Mountains are black bears.