Revealing mistake: When the camera pans across Kareem Abdul Jabar's dead body sprawled out on the steps, the corpse blinks.
Revealing mistake: When Harold Lauder crashes his motorcycle through the guardrail on the mountain road, the stuntman is ejected from the bike before the actual crash.
Continuity mistake: When the judge is being followed through the town of Copperfield by the two guards, the guards are driving a Ford pickup truck with a standard cab. In the first interior shot of the truck, it appears to be an extended cab truck with a gray interior. In the next interior shot (when they are about to get out), it switches back to a standard cab with a red interior.
Revealing mistake: When Stu shoots the doctor in the Vermont Disease Center, the third shot's exit hole appears before the shot is fired. (Seen on DVD)
Continuity mistake: When Stu and Glen are about to meet Fran and Harold, Glen gets up out of a hammock to go and see them. When it cuts to a shot of Stu rushing to meet them, in the background behind Stu, you see Glen getting out of the hammock again.
Continuity mistake: At the start of the film at Haps gas station Campion says his wife got sick in Salt Lake City. Later in the war-room of the CDC the big map on the wall shows that he went south out of northern California and headed east through Arizona and New Mexico before he crashed in east Texas.
Revealing mistake: When Stu and Tommy are making their way back to Boulder, they are towing the snowcat through the snow. In one shot you can see tire tracks in the snow already.
Continuity mistake: When Flagg, Nadine and Lloyd are in Flagg's apartment and he is fixing gin and tonic, he uses a special, tear-drop shaped flask. In the next shot of the bar, the flask is not there. Then, in the next shot when Flagg starts to throw a temper tantrum, it's back. (00:32:15)
Continuity mistake: When Flagg kills the Monster Screamer (Kareem Abdul Jabbar), he (the Screamer) is walking on level ground, and he falls forward clutching his chest. In a later scene Larry and Nadine find the dead Monster Screamer laying on his back on a staircase. The argument that he somehow crawled to the staircase after being apparently instantly dead is invalidated by the fact that his sign is with him on the staircase scene.
Continuity mistake: When Nick is attacked in Shoyo, his hat falls off his head; in the next shot (when he hits/kicks back), his hat is back on, then in the next shot, it is off again.
Continuity mistake: In the scene when Randall is having his temper tantrum in Vegas, he runs to the balcony and tosses a chair. The shot cuts to Lloyd, when RF walks in, his hands are in his front pants pockets. When they cut away, they are in his back pockets. Cut back and in his front again.
Other mistake: Part 3 - The Betrayal: Fran tells Stu that she's pregnant on July 19th, and the way she tells him implies Stu is the father, and she's due in January. It's impossible. They didn't even meet until early July. Counting backwards from January, nine months lands in April. Way before the super flu even escaped. Way before the movie is set. (00:05:45 - 00:06:08)
Continuity mistake: When Nick Andros gives Tom Cullen his bike Tom climbs on with no backpack. When you see him pedalling around the mannequins he has one on. (02:19:56)
Continuity mistake: When Nick sits next to Tom on the bench the Pepto Bismol bottle is and then is not there when they get on their bikes.