Factual error: Near the beginning when the boat pulls up and the guy on the boat tells the blond convict he's got a beauty 13 foot "Tiger shark" that's up in some sort of sling, the so called tiger shark is actually the same robot mako shark from the rest of the movie, just with stripes on it. Tiger sharks have a blunt rounded nose, not a pointed one like a great white. (00:07:35)
Factual error: A double oven has a double or triple insulating wall between ovens, not a single sheet of flimsy steel. (00:56:00)
Factual error: Since the water was always waist high, how could the huge sharks swim inside? Not to mention the corridors... (00:51:10)
Factual error: Despite the massive size of the sharks, there's no way that the waist high water would be completely covering the shark. Right before attacks, no one sees a shark until the dorsal fin comes up out of the water.
Factual error: Late in the film, Susan is wearing rubber aquatic shoes. She goes to her quarters to retrieve the data and decides to electrocute the shark that attacks her. She takes off her rubber wetsuit and stands on it on the metal table to insulate her from the current so she doesn't get electrocuted herself. But, isn't she already insulated by the rubber on the bottom of her shoes? Was this just a reason to get her to take her clothes off?
Factual error: Without wanting to go into extreme details, the genetics and biochemistry of the entire film is flawed. No geneticist in their right mind would even think about using gene therapy - a technique which is not entirely successful yet - to increase the size of the gland. One would use any of multiple techniques to identify and clone the gene responsible for the protein in question. It is cheaper, more successful, and a lot safer and quicker to do. A copy of the gene could be inserted into E. coli and produced on a mass scale in a beaker on land. After the protein had been isolated it would not be able to be given to patients in a pill form because it would be digested in the gut (like insulin for diabetics). (00:05:20 - 00:48:55)
Factual error: After the doctor returns to her quarters and retrieves some papers, she is trapped on a table or a desk or something and she pulls out a wire that shocks and kills the shark. Isn't it convenient that the jolt ends for some reason right when the shark dies, even though the circuit would have stayed intact and she would have been shocked upon entering the water. (01:23:10)