Continuity mistake: When Preacher says "Leave that to the white folks, brother" to Franklin you can see that Preacher looks rather serious. When it cuts, he is instantly smiling. (00:19:20)
Continuity mistake: When we first meet Preacher and he is feeding "Bird" some cream off his finger, the amount of cream on his finger changes between shots. (00:17:05)
Continuity mistake: When Carter is swimming down to the hatch, just after the technician has been eaten, you can see that when there's a shot showing what he can see, there's a straight beam of light presumably from his torch as that's the only source it could come from. However, when the camera moves back to see Carter swimming through the water, you can see that the torch he is carrying is moving around violently as he is trying to swim to the hatch. There's no way Carter could have held that torch straight enough for it to produce such a straight beam of light, especially since he's busy trying to escape being eaten by a freakishly smart shark. (01:17:35)
Continuity mistake: At the start of the film when the man is trying to remove the licence plate from the sharks mouth you see a shot of him holding on to the fin on the huge shark from above the water. you can see the man is a good bit away from the mouth of the shark yet when we see the underwater shot he is just finger tips from the license plate. (00:09:20)
Continuity mistake: Look carefully at the licence plate when Blake removes it from the shark's mouth. It bends and flexes as though it's made out of rubber or even cardboard. Of course in the next scene when he throws it on the walkway, it's an ordinary licence plate. (00:09:30)
Continuity mistake: In the part where they are climbing up the ladder and there's fire on the roof, just after the shark attack Preacher comes and pulls them up with knotted clothes, then he pulls it in with them through the door. When they go back the knotted clothes are there again.