Plot hole: Early in the film, we learn that the former prostitute Annie Crook is married to and has an infant daughter (Alice) with Prince Edward Albert Victor. Secretly outraged, Queen Victoria dispatches various high-ranking operatives to eliminate this potential royal scandal. To that end, Prince Edward Albert Victor is secreted away, and his wife Annie Crook is kidnapped and barbarically lobotomized. We then learn that he baby, Alice (who was fortunately in the care of two other prostitutes at the time of the kidnapping), was sent to live with the parents of Annie Crook, no doubt saving the baby's life. That is the last time we hear of baby Alice until near the end of the film, where we are puzzled to learn that Alice was not sent to live with her grandparents at all, as stated earlier. Rather, the prostitute Mary Kelly took baby Alice away from an orphanage to raise as her own. No explanation is offered for this discrepancy.
From Hell (2001)
1 plot hole
Directed by: Albert Hughes, Allen Hughes
Starring: Heather Graham, Ian Holm, Johnny Depp, Robbie Coltrane
Factual error: Towards the end of the movie, Mary sends a hand-written note to Inspector Abberline. The 'r' in her name is written in a North American style, where she is European.
Jack the Ripper: I shall tell you where we are. We're in the darkest region of the human brain, a radiant abyss where men go to find themselves.
Netley: I don't understand, sir.
Jack the Ripper: Hell, Netley. We are in hell.
Question: Did Abberline use drugs to see visions after his wife and child died, or had he used them before?
Answer: It's not known if Abberline used Absinth before his wife died. But I doubt that he would have used Absinth or any other form of drugs when he was married.
Answer: The real-life Abberline didn't use opium or absinthe or anything else, and he wasn't psychic, and he and his two wives never lost any children nor had any children. Aside from the very few facts regarding the Ripper murders, everything in the movie is fictional, fake. Therefore, irrelevant.
I think those questions are meant for the fictional movie not the real story of Abberline.
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Answer: Johnny Depp said in an interview that Abberline was a hypersensitive guy and had a lot of demons and a dark history. He probably start doing drugs to feel numb against the pain that he lost his wife and child since he desperately wanted a family.