Plot hole: Early in the film, we learn that the former prostitute Annie Crook is married to and has an infant daughter (Alice) with Prince Edward Albert Victor. Secretly outraged, Queen Victoria dispatches various high-ranking operatives to eliminate this potential royal scandal. To that end, Prince Edward Albert Victor is secreted away, and his wife Annie Crook is kidnapped and barbarically lobotomized. We then learn that he baby, Alice (who was fortunately in the care of two other prostitutes at the time of the kidnapping), was sent to live with the parents of Annie Crook, no doubt saving the baby's life. That is the last time we hear of baby Alice until near the end of the film, where we are puzzled to learn that Alice was not sent to live with her grandparents at all, as stated earlier. Rather, the prostitute Mary Kelly took baby Alice away from an orphanage to raise as her own. No explanation is offered for this discrepancy.
Continuity mistake: When Abberline draws the knife on the board its lines are jagged. When it cuts to different angles of the board the knife is completely different, smooth lines and it seems much larger and it is perfectly aligned on the board.
Jack the Ripper: I shall tell you where we are. We're in the darkest region of the human brain, a radiant abyss where men go to find themselves.
Netley: I don't understand, sir.
Jack the Ripper: Hell, Netley. We are in hell.
Question: Did Abberline's wife die while giving birth, or after it? And how did the baby die?
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