Continuity mistake: Janet escorts the two rich clients to their cabin, which happens to be literally next door. Forgetting the fact that it looks nothing like the luxury quarters of a plane, let alone a casino with millionaire bets, she closes the door, but then she comes out of the door that is still open. (00:23:40)
Revealing mistake: During the "green storm", the co-pilot finally gets to her station. Cut to the playroom, and one hilarious CGI bottle of booze spins around in the air being blatantly superimposed. (00:14:30)
Character mistake: The very advanced computer on the plane can't spell, since it infers probabilities that a member of the crew has been "INFECTETED" by the creature. (01:06:40)