Dr. Grace Hart: Shall we begin the autopsy? Dr. Grace Hart.
Watson: A woman doctor?
Holmes: Impossible. Fortunately we have a real doctor here.
Watson: Would you like some heroin?
Holmes & Watson (2018)
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Directed by: Etan Cohen
Starring: Ralph Fiennes, Will Ferrell, Rebecca Hall, Kelly Macdonald
Factual error: Though the movie is playing with historical events for "laughs," it should at least be pointed out for the record that Queen Victoria died in 1901, and the Titanic didn't launch until 1912 (and its construction didn't even start until 1909). So, obviously, there's no way Victoria could have toured it before its maiden voyage. (And the movie acknowledges that it's supposed to be THE Titanic since it shows Moriarty reading a newspaper reporting that it sank, to say nothing of the Billy Zane cameo).
Trivia: The American and international versions of the film have different opening sequences. In the American version, Holmes and Watson meet in school. In the international version, Holmes (accidentally) saves Watson from committing suicide.