Factual error: Lori takes a screwdriver to the left hand side of her abdomen. The doctor says it just missed her liver and she has lost a lot of blood. The liver is on the right side of the body and nowhere near where she took the injury.
Factual error: Our heroes find a boat belonging to shark poachers, smashed to pieces by the Meg. Floating about in the debris are the bodies of a number of dead sharks. Sharks do not have swim bladders and dead sharks do not float - they sink.
Other mistake: At the end, the ship has exploded after the crash of the helicopter and the crew is in the water. The woman is picking up the people from the water in her surfaced sub. How is this thing propelled if both forward thrusters are above water?
Continuity mistake: When Jonas is pulled from the ocean, after shooting the tracker into the Meg's fin, there is an overhead shot of everyone moving to the back of the boat to see if Jonas is all right. A moment later, just after Suyin looks down at him, the same overhead shot repeats. (00:55:20)