Continuity mistake: When the class is in Arnold's esophagus, Tim says something, then it cuts back to Ms. Frizzle. Arnold is sitting in the back seat of the bus.
Sins of the Fathers Chapter 1: Doctor Strange - S3-E1
Revealing mistake: When Mary Jane and the other servants of Baron Mordo are flying through the city, they literally disappear into thin air. Probably a problem with rendering the 2D animation within the 3D animation. (00:01:00)
Coach Fussell's Lament - S2-E5
Continuity mistake: Chairface and Chrome Dome arrive at the Brianchild's house in the same car, but drive off in separate cars.