Factual error: In chapter 21 Vittoria states that "everything has an opposite. Protons have electrons." Protons and electrons are NOT opposites. The opposite of a proton is an antiproton, the opposite of an electron an antielectron (or positron). Other than having opposite charges, a proton is completely different from an electron, ie. a proton is a hadron made from 3 quarks, Up Up Down, making it a baryon. An electron is a first generation lepton and is a fundamental particle. As a physicist, Vittoria wouldn't make this mistake.
Plot hole: The main reason the antimatter bomb was not found, according to the book, is because it is small enough to be hidden anywhere. However, there was a wireless camera watching the bomb all the time. The wireless camera, just like any wireless device, is basically a radio transmitter and receiver, so all they would need is a device displaying the signal strength coming from the camera (having no such device, the CERN could probably borrow some). Where the signal is the strongest, there is the bomb. It is improbable that there wasn't a single person understanding how wireless devices work.
Factual error: In one of his lectures Robert Langdon tells his students that the Christians got their tradition of communion, eating their god, from the Aztecs. The Aztec civilization dates to the 13th century while the tradition of communion is as old as Christianity itself. And even disregarding when the Aztecs lived, the Europeans had no contact with America until the late 15th century and could thus not have gotten any traditions that way.