Continuity mistake: In the scene where Ethan is in the NOC list room Krieger starts to drop him and Ethan is hanging there for a little while. Suddenly some sweat starts to drip down his glasses and he catches the drop with his hand. If you look at how close he is to the floor this move would be impossible.
Factual error: The vents that Hunt and his sidekick crawl down at CIA Headquarters are standard galvanized iron box vents; they are very common in the building trade. Try walking or crawling down one - you'll make a noise like the sky is falling down. People will be able to hear you for miles. Every person in that building would know somebody crawling about in the vent system. (This error applies to dozens of films, not only this one).
Continuity mistake: When Ethan is being lowered into the room with the NOC List, he has the digital temperature gauge. As Ethan is going down, the gage is right side up so you can read it normally. However, Ethan is upside down, and therefore so are the camera glasses he is wearing. Now when we see the computer screen that Ving Rhames is using, the gauge is right side up there, but it should actually be upside down.
Factual error: When the helicopter blows up, the train stops dead in its tracks almost instantly. A high-speed train like the TGV needs more then two miles to come to a complete stop from its top speed, or at least from the speed it's traveling at. And a Little Bird attached to it wouldn't make the slightest bit of difference.Friso94
Factual error: When Ethan is lowered into the computer room at Langley, he is dropped and nearly lands on the pressure-sensitive floor. When an object moves through the air, it pushes the air in front of the object. As the floor sensors were set so high that a drop of water was sufficient to set an alarm off, the air displaced during Ethan's fall would have triggered them too.
Factual error: The train is running on the right-hand track, but in the UK and France trains normally run on the left-hand side. In the rest of Europe and the US, trains run on the right-hand track.
Revealing mistake: When Ethan uses the magnetic screwdriver to undo the screws holding the grille to the air-vent in the NOC list room, the spindle that is actually turning the screw is visible after it falls out.
Continuity mistake: At the end of the movie, when Ethan and Luther are sitting at the pub, just after the cheers/here's to you speech, Luther said "Hey, I'm flavour of the month" and brings his glass up to his lips for a drink. In a split second cut to a wide shot facing Luther his glass is on the table, and there are only two glasses on the table as established in a wide shot where Ethan says, "I'd better go catch my flight."