Revealing mistake: McClaren breaks out of a building through the picture window. The glass breaks not as a normal window would, but fragments, as if it were sugar glass or similar. It's really obvious.
Visible crew/equipment: When Steven Seagal and his daughter flee the hospital bunker, the shadow of the camera following them is visible on the doorway. (01:17:35)
Continuity mistake: Earlier in the film Steven Seagal explains that in his lab they used plastic beakers because glass can cut the monkey suits.Later in his lab they are using pyrex beakers and when they clink together, they are clearly made of glass.