Continuity mistake: When Eddie is transforming into a wolf in front of Karen his left hand turns grey and grows hair down to the knuckles. Then in the shot of his arm muscles expanding, his left hand has a normal skin color and hair only down to his wrist. Apparently, while editing no one checked to see how his hand was already established. (02:09:55)
Donna: Haven't you ever done Assertiveness Training? Before I looked into the Doc, I did it all - EST, T.M., Scientology, iridology, Primal Scream... I don't know, I figure another five years of real hard work, and maybe I'll be a real human being.
Trivia: While giving a lecture at the Hollywood Scriptwriting Institute, director Joe Dante trash talked the novel "The Howling" on which the movie is based. One person in the audience raised his hand and asked, "So, you don't like the book, huh?" with Joe stating, "No, not really." The man responded that he was the one who wrote the novel. To Joe's surprise, the man in the audience was Gray Brandner, the author of "The Howling."
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