Frank (Nicolas Cage) is a paramedic who's about to take us on a tour de force that is his job as an EMS paramedic. Frank works the graveyard shift and in much need of a break. Going from here to there in the city streets, he keeps seeing the ghosts of the people he couldn't save. Joining him on this journey are Larry (John Goodman), religious Marcus (Ving Rhames) and hot headed maniac Tom (Tom Sizemore). Frank meets Mary Burke (Patricia Arquette), whose father has recently suffered heart trouble.