Question: Towards the end of the film, Heather steals the Seal from inside of Leonard, and we see him burn up. But the shot goes noticeably out of focus when this happens. What gives? The scene appears to be CG, so it makes no sense for it to go so badly out of focus. Were they just trying to cover up a dodgy effect?
Question: After they escape the safe house, Weston calls the CIA and says "no chance of an SDR, I've picked up a tail." What does SDR stand for?
Answer: "Surveillance Detection Route." It's what you do when you think you're being followed (drive a specific route to detect if you're under surveillance or not). Weston says "I think I might have picked up a tail", so he was unsure if he was actually being followed or not, but had no time to try and determine if he actually is being tailed or not.
Answer: I believe your theory is correct, it appears to go out of focus to help cover up some unconvincing CGI. The final explosion looks very cartoonish.
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