Plot hole: When Kuzco and Yzma make a dive for the potion bottle, Yzma is turned into a cat simply by landing on the potion bottle. This suggests that a person only needs to touch the potion in order to be affected. However, when Kronk and Yzma are serving Kuzco dinner and are trying to avoid poisoning themselves, Kronk pours his potion drink on himself and is not affected.
Plot hole: Ginger can hold Mrs. Tweedy single winged. She can also tip up a feeder full of food. So now we have clarified that she is one ridiculously strong hen, how does she need help pushing up a deck chair? 3 other chickens were able to do it with ease earlier.
Plot hole: There's no visible evidence that Team Rocket has taken away Ash, Misty, and Brock's Poké Balls when the gang was in the cage, so why don't the Trainers call out their Pokémon (Brock's Onix would've helped out very much) and escape the cage?