Deliberate mistake: At the start of the movie when the articulated truck is leaving the aircraft, you never see the attached trailer until the truck is completely flat on the runway. This is because of the steepness of the loading ramp, the trailer would ground and get stuck on the ramp.
Deliberate mistake: When Marge and Dick are being beamed in outer space, there's no way they could be breathing because there's no breathable air in space.