Continuity mistake: If you look carefully at the monster (Frankenstein) you will see that his face is different in the ending scenes. The reason is, during the movie you see the monster take the woman doctor and throw her out the laboratory window. You then see the monster kind of stumble, which he really did and broke his ankle. So in the final scenes they replaced Lon Chaney Jr. as wolfman with a stuntman, and Lon Chaney Jr. finished the movie as the monster.
Plot hole: When Ralls runs the Witch onto the reef, he is at the helm. As she strikes bow on, the wheel spins madly for no reason, as the tiller ropes would not have been affected by the collision.
Continuity mistake: While fishing, Mr. Peabody hooks a mermaid who is swimming underwater. When he reels her in and she leans over the edge of the boat, her hair is completely dry and perfectly coiffed.