KSG

Question: Is there any relationship or plot dependency on the Clock Maker family and Benjamin Button's birth parents?

Answer: It's setting up the story, so you could interpret it your own way. But as far as I can tell, there is no specific relation, just setting the story up.

KSG

Answer: Yes. The wife of the clock maker is the same person as the mother of Benjamin Button through adoption.

Where did you get this information? Queenie (who adopted Benjamin) was a nursing home worker married to Tizzy Weathers, and not married to Mr. Gateau, right? My understanding was the clock that ran backwards was revealed the same time Benjamin was born (or at least the same year, 1918).

Bishop73