Factual error: During the St. Louis part, they show the Griswolds crossing the bridge into Missouri and *then* getting lost in what they title "East St. Louis." East St. Louis is actually in Illinois, so they would have encountered it before crossing the bridge. This has apparently been corrected in the video version.
Factual error: After they leave Dodge City, Ellen says they should stay on US-50. US-50 in Kansas is not a 4 lane, divided highway. In the same scene, as Christie Brinkley approaches in her Ferrari, there are mountains visible in the background. There would be no mountains visible anywhere in Kansas.
Factual error: The whole movie he drives without any valid license plate. Just a crooked colored plate from the auto store. He would have been pulled over for that immediately, and the car probably would be impounded. Then when he does get pulled over for the leash, the cop says nothing about invalid plates. But he asks for registration proof and Clark shows it, even though he has no legal plates. Plus his meaningless plate is crooked, which is also illegal.