Ryan Reynolds is actually a godlike being who created multiple universes and put himself in as a character in each one. Susan is another being like him who is trying to get him to leave the world he created. He eventually does so by pulling off the green thread around his wrist, causing reality to collapse. He creates a new world for Margaret and Noelle with a new father, which is supposed to be the 'best of all possible worlds'. Noelle tells her mother that he isn't coming back.
Continuity mistake: In the beginning of Part 3, Ryan Reynolds is on a deserted two-lane highway asking Hope Davis for help. She refuses to help, begins to turn and walk away down the double-yellow center lines of the road. In the next shot, we see her finishing the turn and walking on the edge of the road, by the white line (facing traffic). Immediately after, she is shown on the right side of the road, on the other white line (walking with traffic). (01:14:15)
Gary: This is all a dream?
Gary: I'm in a coma?
Gary: I'm dead? This is hell or purgatorium or something?
Margaret: Okay, purgatorium is where Romans vomited, but no, this is as real as anything can be.
Gary: What does that mean?
Margaret: Everything is what it is. You're not who you think you are.
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