A man witnesses a gangster (Eddie Kim) kill a prosecutor who had tried several times to send Eddie to jail. The witness is then convinced to testify against Eddie. The murder occurred in Hawaii, and they have to fly to LA. Snakes are in the cargo hold on a timed cage (apparently security didn't catch them because they are cold blooded) and were, of course, placed there by Eddie Kim so that the witness would not survive. The first people to die are a few kids joining the mile high club and one of the pilots. Then snakes start coming from everywhere and the passengers have to fight them off/barricade themselves from the overly aggressive snakes. The second pilot ends up dead and a man with experience flying planes on his PlayStation2 ends up landing the plane safely.