Trivia: The movie was originally titled "The Lost City of D," which was believed to be a play on the non-fiction book and biographical movie "The Lost City of Z." However, the movie was simply retitled "The Lost City." While no official reason was given, it's widely believed that "of D" was dropped because in recent years, the letter "D" has been adopted and widely used as a euphemism for the word "d**k," almost exclusively with sexual connotations. (Which in fact is joked about in the movie itself).
Trivia: The film was meant to reunite Sandra Bullock and Ryan Reynolds, who had worked together earlier on the popular 2009 rom-com "The Proposal." However, Reynolds was unable to appear in the film for one reason or another, and his part instead went to Channing Tatum.
Trivia: There's a common complaint that often in movies, male actors are significantly older than the female actresses who play their love interests... sometimes to the point of it being flat-out creepy. By contrast, "The Lost City" has one of the rare movie romances in which is the female lead is older than the male. Star Sandra Bullock is actually 15 years older than Channing Tatum, who plays her love interest.
Trivia: Many people have noted that the basic premise of the film is very similar to the classic movie "Romancing the Stone." This fact was not lost on the crew, who threw in a few homages to it. Not the least of which being that the book tour in the film is called "Romancing the Page," and the fact that Brad Pitt is named "Jack" - the same name as one of the protagonists from "Romancing the Stone."
Trivia: There is an extra scene after the credits roll with Brad Pitt Sandra Bullock and Channing Tatum in a meditation room.