Continuity mistake: At the beginning of the episode, when Meredith, Derek and Zola see the lion crossing the street in front of the car, the lion roars and it is clear that the lion is not missing any teeth. However, later in the episode, Richard removes a tooth that had gotten lodged in the male mauling victim's arm.
Continuity mistake: We see a nurse writing down "Yang, C" on the assignments board; note the handwriting. Later, when Burke notices that Christina's name is on the board, the handwriting of "Yang, C" is completely different and other minor writing differences are noticeable too.
Continuity mistake: The scene where the bomb explodes shows the bomb squad captain walking toward the end of a hallway. Just as the bomb explodes you can see he is about 5-6 feet away from the end of the hallway where another bomb squad tech is waiting. After the explosion the scene cuts to Meredith flying backwards then to a shot of windows being blown out then back to a rear shot of Meredith hitting the floor. Notice here that a second floor is not visible at the end of the hallway. The scene finishes with a final aftermath shot of the hallway as the debris settles. Here we see an entirely different hallway with a visible second floor and the end of the hallway extended by about 10 feet.
Continuity mistake: At the very start of the episode when it shows Burke laying on the floor after being shot, there is a very large pool of blood with his glasses right next to the blood. But in the next shot there is no pool of blood anymore but it returns in the next. Additionally, the pair of glasses change position.
Continuity mistake: When Derek sits in the rocking chair in the room with the premature baby and then Addison starts listing their relationship options, the blanket hanging over the back of the rocking chair constantly changes position, evident by the green stripes on it.
Factual error: Derek tells Meredith to do an MRI on the lady that has a fork stuck in her neck. But an MRI-machine is actually a huge magnet; that's why there's absolutely no metal allowed inside of it. Doing an MRI on someone with a fork stuck in her neck is extremely dangerous.