Series 
Continuity: When Izzy, George and Christina walk over to the vendor, talking about Dr. Sheppard and Meredith, Izzy is in the middle, eating snacks from a packet. Between shots she alternates from holding the pack either up or down.
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Quotes
Dr. Meredith Grey: Do you like Izzie? Is that was this is about? You have a crush on Izzie?
Dr. George O'Malley: Izzie? No! I don't like Izzie. Izzie? No! She's not the one I'm attracted to.
Dr. Meredith Grey: Not the one. So there's a one?
Grey's Anatomy (2005) - 3 mistakes in "The Self Destruct Button"
starring Ellen Pompeo, Isaiah Washington, Katherine Heigl, Patrick Dempsey, Sandra Oh (add more)
The Self Destruct Button (season 1, episode 7)
Visible crew/equipment: When they arrive at work near the beginning, as Meredith exits the car, and walks past, the boom mike is reflected in the car, in front of her, following her along.
Continuity: At the beginning of the episode, Izzy takes a purple plastic cup of coffee with her to work. In the parking lot she now has a coffee in a disposable paper cup. Then in the locker room, she is back to having the purple plastic cup of coffee.
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