Other mistake: When Moe is running to the Simpsons' house there is a shot of him running past the moon. When running back to the bar, the same shot is used but is simply flipped. Note the house and rocks. (00:18:20)
Continuity mistake: When Moe confronts Jimbo, Jimbo has his back in a corner with just a cabinet behind him. When the shot changes he is next to the green chair. (00:19:00)
Continuity mistake: When Bart is out in the hallway being attacked by the wolf, he is missing his right shoe. When he goes into class he is missing his left shoe. (00:18:40)
Continuity mistake: When we see Krusty with a bird on his head, the claws' position on Krusty's head change. Note his left eye. (00:16:20)
Continuity mistake: Smithers opens the second case for Tom Jones as the green gas has all but dissipated from the case. When the shot changes, there is still gas coming from the case. The remaining gas also changes place in the vicinity of the case. (00:15:50)
Continuity mistake: When Tom Jones walks off-stage a towel appears around his neck instantly between instant camera cuts. (00:16:00)
Continuity mistake: When we see Smither daydreaming about Mr Burns coming in through his window at night, the painting on the wall disappears between shots. (00:14:50)
Continuity mistake: When Burns is lay on the floor telling Smithers that he dreamed of Marge again last night, the painting behind Smithers is very badly painted and very childish in appearance. Burns' head is completely disproportionate for example. When the shot changes to Smithers the painting is now a lot more detailed and no longer looks childish. (00:14:42)
Revealing mistake: When Homer points at the donut guy, his right shirt cuff is colored yellow. (00:12:50)
Other mistake: When Homer pretends to read the newspaper, the back page is very noticeably blank and missing any print. (00:08:00)
Continuity mistake: During the musical number about Mr. Burns, Homer and Marge swap sides of the table. (00:05:40)
Revealing mistake: At the start when we see stuff falling off the roof, the animation for the swings in the background simply fade out and are incomplete. (00:02:05)
Itchy and Scratchy: The Movie - S4-E6
Continuity mistake: When Bart places his money on the kiosk, the end of the note is overhanging the edge of the kiosk. When he grabs his money after being refused entry, the entire note is on the kiosk. (00:19:20)
Itchy and Scratchy: The Movie - S4-E6
Continuity mistake: When Bart tries to buy a ticket to Itchy and Scratchy, the booth is unoccupied. When the shot changes the man has appeared in the booth. (00:19:20)
Itchy and Scratchy: The Movie - S4-E6
Revealing mistake: When Nelson blinks right before Milhouse says "No one who saw the movie would say that", Nelson's right eyelid is white for some reason. (00:18:20)
Itchy and Scratchy: The Movie - S4-E6
Continuity mistake: Homer rips up Bart's ticket and the bits land on the floor. Only to simply vanish into thin air. (00:15:20)
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer