As an abstract signature, Sam puts the oldsmobile from "The Evil Dead", in all of his movies. It is an 1973 Oldsmobile Delta Royal. The car has been in every one of Sam Rami's films except for Quick and the Dead. The automobile has belonged to Sam since high school and was speculated by Bruce Campbell that it was so important to the director because he lost his virginity in that car. Hey it is a very roomy car. Uncle Ben is driving that same Oldsmobile when giving pete a ride to the "library".

Randy Savage, who plays "Bone Saw" McGraw started his wrestling career as a masked wrestler named "The Spider"

When Peter begins his transformation into Spider-Man in his bedroom, there is a shot showing synaptic nerves firing in his brain. This is the same shot used in Darkman when he becomes angry and breaks the fingers of the man who doesn't want to give him the pink elephant.

Just an observation, but at the beginning of the movie when we first see Mary Jane on the school bus, she is dressed in the Green Goblin's (from the comic book, anyways) colours. Her top is purple and her coat is green.

When creating Spider-Man, Stan Lee purposely put the "dash" between Spider and Man so fans wouldn't mistake him for Superman since the names are so similar.

Several times in the movie, a character will reference one of the comic book titles, when referring to Spider-Man. This is most noticeable when the ring announcer calls him, "Amazing."

During the scene when Spider-Man is saving the baby from the fire, he must go back into the burning building to save a screaming woman. For anyone who plays the Sony Playstation and has played Parasite Eve II will easily recognize those screams from the game, when Aya must go rescue the screaming woman from the room in Dryfield that is behind the bolted cabinet. The filmmakers took those voice overs right from the video game.

Peter Parker says 'tally ho' before swinging on his web for the first time. In the director's cut of Army of Darkness, also directed by Sam Raimi, near the end, Ash says the same thing before swinging on a rope to knock Evil Ash off the castle top.

In the scene where Peter meets Mary Jane just after her audition, he tells her "I was in the neighborhood", then goes on to list how many taxis & buses he had to take to get into the neighborhood. This is the exact same line said by Liza Minelli to Dudley Moore in the film "Arthur," at Arthur's engagement party.

The Moondance diner that Mary Jane works at is the same diner that Monica works at in the TV show "Friends" during its 2nd and 3rd seasons. It's the theme restaurant for which she has to wear the flame-retardant breasts.

At the Oscorp fair, Spider-Man saves a boy from the balloon that's falling on him, and the same boy is on the tram that Spider-Man catches as it's falling.

Not a mistake, more of an egg...When Peter gets home after seeing MJ at the diner, he mentions to Harry about getting fired by Dr. Conners for being late. Dr. Conners is also known as the Spider-Man villain The Lizard. Also, during the first scene with JJJ, he tells his staff to get better pictures of Spider-Man and the black guy responds, "Eddie has been trying all week"...This could be Venom, aka Eddie Brock who was also a reporter for the Daily Bugle. Could these have been hints as to future Spidey villains?

If you go to the end of the credits, there is the 1960's cartoon theme of Spider-Man.

The scientist assisting Norman Osborne, who he then kills, is named as Dr Mendell Stromm, the same as a character who became The Robot-Master in the comics and was an enemy of Norman before we found out he was the Green Goblin.

In the wrestling scene when Peter has just gotten up the stairs to see the wrestling match (before he signs up) the announcer announces the next fighter to fight Bone Saw. The fighters name is The Flying Dutchman which is the title of one of the old Spider-Man TV shows involving Mysterio.

Bit of trivia - when Peter Parker finally gets the nerve to talk to Mary Jane, he nervously says "Let's get some lunch some evening". This is exactly the same line the hero of the Sam Raimi film "Crimewave" says when he asks the heroine out. Is Sam Raimi thumbing his nose just a little at the critics of "Crimewave"? I think so. Also, the same yellow Olds was used in the final chase scene of "Crimewave" (as in most Sam Raimi films) along with a lot of the same stunts (punch through the windshield, etc).

Not really a mistake just something to see, at that youth festival when the Green Goblin throws his grenades and the crowds react, right before they get a shot of Parker, you see Stan Lee (creator of Spider-Man). He was supposed to originally pick up the little girl that he was pushing to safety, but he's quite old now, and after several takes he said that if they wanted him to pick her up, they were going to be there all day.

During the Thanksgiving dinner that occurred right after the fight in the burning building, notice the clothes Peter and Norman are wearing. Peter is wearing a green shirt (the Green Goblin's color), Norman wears a blue shirt with a red tie (Spider-Man's colors). Also, Harry is wearing all of the colours - green shirt, red tie, and blue coat.

Subliminal product placement? During the Thanksgiving dinner scene, as Peter clings to his bedroom ceiling, a drop of blood gathers on his arm. The sound of the blood falling and hitting the floor sounded a lot like the famous ketchup splat from the Carl's Jr. TV ads. No guesses as to which fast food chain features Spider-Man toys with its children's meals.

The scene where Toby McGuire catches Mary Jane's tablet and the food was done with no computer tricks - it was an actual stunt. The only tricks used here were that the tablet was glued to McGuire's fingers and the foodstuffs all had glue on their bottoms in the shot where he catches the perishables.