The Big Bran Hypothesis - S1-E2
Audio problem: When Penny is talking to Raj on the stairs to the apartments, during some shots we see her from behind. In one shot, we hear her say something like "And I'm freaking out", but you can tell by the way her jaw moves that she was actually saying something different. (00:14:50)
The Hamburger Postulate - S1-E5
Audio problem: When Leonard and Leslie continue to practise together after the other two musicians have left (Leslie now being the only violinist), vibrato from a violin can be heard - from observing Leslie's left hand she is not applying it.
Audio problem: When Sheldon is knocking on Leonard's door at the start, the sound is out of sync with the action.
Chosen answer: It does. The variable cleanliness of the cab and the habit of taxi drivers to engage customers in small talk would be too much for Sheldon to handle, and not an option for him.
Captain Defenestrator