Continuity mistake: When Sheldon is looking at his socks that Penny paired up, his grip on them changes between shots. (00:06:00)
Continuity mistake: Penny throws Sheldon's sock down on the table, and their positions change when Sheldon picks them up, despite no one touching them. (00:05:50)
The Barbarian Sublimation - S2-E3
Revealing mistake: When Sheldon gets the sword for Penny in the game, Penny walks out and you can see the laptop isn't switched on. (00:07:55)
The Barbarian Sublimation - S2-E3
Continuity mistake: When Leslie and Sheldon are talking to Dr. Eric Gablehauser in his office, in one shot Eric throws a piece of paper onto the desk behind him (next to the computer.) Through the rest of the scene, this piece of paper keeps changing position. (00:09:00)
The Cooper-Nowitzki Theorem - S2-E6
Continuity mistake: When Raj says there is always a catch, Leonard's hand goes from on the table to on his leg between camera cuts. (00:03:00)
The Griffin Equivalency - S2-E4
Continuity mistake: When talking to his parents, Raj's grip on the laptop changes between shots. Note the side of the screen. (00:18:10)
The Barbarian Sublimation - S2-E3
Continuity mistake: When Penny is talking to Sheldon in his bedroom, her hands are constantly changing positions between shots. (00:08:45)
Continuity mistake: When Leonard shows Penny the leaflet at the end, she is holding it in one hand in shot but with 2 as the camera changes. (00:19:50)
Continuity mistake: Leonard says that Sheldon has gone crazy and chucks his pen down on a red pad on the desk. When the shot changes, so does the position of the pen without being touched. (00:13:10)
Continuity mistake: In the laundry room, Sheldon is holding a blue shirt in his hands and has a bit of extra material near his hands. When the shot changes, he is holding the shirt differently and the extra material has gone. (00:05:50)
Suggested correction: Genes can be dormant. Which allows them to skip generations. Therefor Missy's children could actually get the "mutated" gene. This is especially true since Sheldon and Missy are twins. Also, since the episode is about who out of Leonard, Howard or Raj, Sheldon would allow to "mate" with his sister, there is the added "insurance" of getting any smart genes from any of the 3 Lothario's mentioned above.
If you are going to try to argue with a geneticist about genetics, please use the correct terms. Sheldon is not referring to a recessive gene - there is no such thing as a dormant gene - he is speaking of a randomly mutated gene. Those are the words he used. If he had inherited a homozygous recessive karotype - one recessive gene from each of his parents - then somewhere in his family tree there would similarly gifted people, in which case he would use the correct term - a recessive gene. If Missy is a heterozygotic dominant karotype possessing the recessive gene for super-genius and the dominant for ordinary intelligence then mating her with Howard, Raj or Leonard would be a waste of time as their dominant genius gene would prevent the recessive super-genius gene from being expressed in the phenotype of the resulting child. The child would be highly intelligent but not on Sheldon's standards. It doesn't matter if Sheldon does not know any of this as he refers several times to a randomly mutated gene, not a recessive one. Missy does not carry the super-genius gene. The posting is correct.
Sheldon is prone to magical thinking when necessary to preserve his obsessive need to control his environment. He may have simply ignored the flaw in his reasoning, as even the most intelligent humans do when venturing outside their ares of expertise. He may be interested in the science of genetics, but his Ph.D. in physics doesn't qualify him as an expert in that field.