The drill that Lynn uses on Jigsaw's skull has a white piece of tape on the end of the drill bit a short distance from the end, presumably to mark the thickness of his skull so she knows where to stop. In one shot (during the drilling scene) the piece of tape moves a good two inches farther up on the drill bit, but it's back down in the very next shot. See more...
During the brain surgery scene Jigsaw relives a romantic scene in a park, during one of these shots you can see the character Obi who was burned to death in Saw II. See more...
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When Lynn is inspecting the "reverse bear trap", the trap Amanda was placed in for the first movie, you can see a small orange light reflecting off a few surfaces, like Lynn's arm and the nearby table. This is the brightness level auto-adjustment light that is present on many handheld cameras, which the cameraman apparently forgot to cover or turn off.
Picture submitted by Starchild
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