Bludworth: In death, there are no accidents, no coincidences, no mishaps and no escapes.
When Alex's air ticket is torn at the checking desk before he boards 180 if you look at the ticket very closely there is a piece of text saying,'Your Final Flight'. See more...
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Other: At the memorial service the principal says that it's been 39 days since 39 loved ones had died. But there were 40 students on the plane and 4 chaperones, making the total 44. Now 7 people got off the plane which means 37 people related to that memorial service actually died, not 39. Two pilots would make up the numbers, but there would be flight crew too, which still leaves the numbers off.
Factual error: The teens are traveling presumably along the Meadowbrook or Wantaugh parkways, when the enter Jones Beach. They see a sign just before the beach entrance that says "New York: 93 miles", when Jones Beach is less than 15 miles from NYC limits and approximately 25-30 miles from Manhattan.
Other: When the plane takes off in Alex's vision, the plane begins to go into a nosedive, and the entire left fuselage is blown apart, sucking many people out of the plane. The plane then explodes completely, but in reality, the plane just takes off, and explodes almost instantly afterwards. No struggling with the plane is shown in reality, nor is the plane going into a nosedive. This is also proven in FD5, which is a prequel. The jet engine explodes, leaving a flaming tail, and the plane spinning out of control. The plane just simply "explodes" without any signs of struggle.
Continuity: When Ms. Lewton dies, she is grabbing her bleeding neck with her left hand. While walking into the kitchen, she leans onto the kitchen table with her right hand. Later in the scene, when Alex comes and tries to help her, we see the bloody left hand impression on the table, even though we should see the right one.
Deliberate "mistake": At the start when you see Alex, Tod and co. walking down the walkway to the plane you can see that their heads are almost touching the ceiling. You can tell it was shortened to make the path longer for the appropriate sequence and then after when they reach the turning the ceiling is much higher.