Factual error: When any character's automatic pistol runs out of bullets, the slide doesn't lock open. All the weapons shown are of a type which should.

Continuity: A zombie hits its head on a tombstone, which falls over. In the next shot, it's upright again.

Continuity: In the scene were Alice slides on the floor, she shoots up a hole in the wall and goes down it, dislocating a finger on her left hand in the process. In the next shot she straightens it out, and the finger is on her right hand.

Continuity: When the scientists are standing at the entrance to the Hive, one of them opens a small transmitter, reflected in his mask, with its antenna pointing over 45 degrees. When it cuts, the antenna is pointing almost horizontally.

Continuity: When Nemesis blows up the STARS sniper on the roof of the theater, the size of his rocket launcher changes drastically.

Revealing: If you slo-mo the scene where the semi collides with the SUV carrying the doctor's young daughter, you can see the the right front of the SUV is substantially off the ground even before the truck strikes it, presumably to ensure it flips.

Visible crew/equipment: A boom mic operator wearing a white shirt is seen reflected in the door that the female scientist opens, when the Umbrella personnel pick her up, as part of their extraction procedure. He is visible as the door is opening and very faintly when it is closed.

Continuity: In the scene where they're in the school and they split up, Terri walks into the classroom we see that the map in the front of the classroom has bloody hand prints on, but when Jill Valentine walks into the same room later, there are no hand prints on the map.

Plot hole: When Alice talks about how Jill's friend will become a zombie soon and pointing the gun at him, Jill looks surprised, yet Jill had already encountered the T-Virus before. She was a member of the STARS Alpha team who were sent to the infamous mansion in the first game - there are newspaper clippings in her house about "the mansion incident". Jill would already know what happens to people who get bitten, so she would know that her friend is going to become one of them.

Continuity: Watch the remains of the metal bar that sticks out of the building after Nemesis ripped it off to fight Alice. If you look at the point of the metal it is horizontal. When Nemesis is pushed onto it, it is vertical.

Continuity: Watch the scene where Alice almost pokes the scientist with the pen. In the close up shot of the guy's face, she almost poked him in his left eye. In the far shot, the pen is being pointed at his right eye.

Continuity: Nemesis has an ammunition counter for his Vulcan cannon. When Nemesis is shooting at Peyton on the bridge, his counter stops at 3997 rounds. Almost immediately he begins shooting at Jill, but now the counter reads 3688.

Factual error: When the nemesis creature fires a rocket-propelled grenade down the laundry chute/garbage chute at Alice, she protects herself from the blast by a plastic cart. There is no way this would have worked, the plastic cart would have been destroyed along with her.

Continuity: When LJ shows his custom guns to the STARS, he opens his coat and pulls the tail behind his back. In the wide shot, his arms are out to the sides.

Visible crew/equipment: When Nemesis shoots the guy on the roof of the theater, you can see a machine that shoots out fire.

Continuity: In the scene when Alice escapes from Nemesis falling into the garbage, she shows both hands with her fingers in good condition. Yet in the next shot, she has a very badly broken finger.

Continuity: When Alice is asleep and submerged in the water tank her body is in a fetal position. She wakes up and moves around. The water is then drained from the tank, but she's still in the exact same fetal position.

Continuity: At the end, as the doctor walks away from Alice after questioning her, she changes from looking up at him to looking down between shots.

Continuity: In the church, Peyton asks Terri about her video camera. She has it raised to shoulder height. Cut to her face and the camera's gone. The next shot is through the camera and shows the same view of Peyton we could see before over her shoulder, so she didn't move it.