Continuity mistake: When Karen frees Blade, she opens the chamber he was in. But in a later shot, when lightning strikes, the chamber is closed. (01:39:49)
Continuity mistake: In the big fight scene in the end between Blade and Frost, the blood smear on Frost's face changes sides a few times. (01:43:55)
Continuity mistake: After Blade kills his vampiric mother, he runs with his vest in his hands. Then, suddenly his vest on, unzipped. He jumps down onto the center platform, looks up, and the vest is now zipped. (01:46:40)
Continuity mistake: At the end, when Frost and Blade are fighting, Frost punches Blade in the stomach, making him fly back and hit the wall. If you watch closely, his fist never comes close to hitting Blade. (01:50:53)
Continuity mistake: In the shot where Blade knocks the serum down from the wall, he throws one at Frost, then throws five more at him and finally throws the last one in his head. That's seven shots of serum, but when he catches it behind his back there are only six in the pack. (01:51:20)
Continuity mistake: Right before the sword embeds the marble, it's on the right side of EDTA. When the sword handle opens it's above it. (01:51:30)
Continuity mistake: When Blade is leaving the shop towards the end he fills up 6 phials of EDHD, but he uses 9 phials total. 2 on the 2 people in the hall when he first gets to the building and then 7 more on Deacon at the end.
Continuity mistake: In the House of Erebus, right before Blade jumps off the ledge to fight Frost, you see that Karen is standing on the ledge above everything and Mercury is standing down below on the platform. But when Karen's shooting at her, Mercury is coming down the stairs from above.
Continuity mistake: When Karen tells Blade to take her blood and he does, he eventually releases her and there is just some blood on his bottom jaw. In the next scene, there is blood on his teeth at the top and the bottom.
Continuity mistake: Frost says near the end of the film that the spirits of the twelve will awaken the Blood God. Fair enough, but when the prophecy is first translated, you hear twenty beeps as pictures of people pop up around the circle, implying that there are twenty people standing around it.
Continuity mistake: In the beginning of the movie when Frost leaves the meeting, as he leaves the sound from his shoes is delayed.
Continuity mistake: When Frost kills the fake policeman, prior to Frost biting him there are six to seven rubber ducks floating in the water. In the very last shot where the police officer is floating dead in the pool, all of the rubber ducks are gone.
Continuity mistake: When Karen turns on the UV lamp the first time and starts to burn Pearl (the enormous record-keeper), watch closely. In the first shot from the front, Pearl has no burns yet and the air is clear. It immediately cuts to an over-the-shoulder shot and not only does Pearl's arm instantly have burns on it (that had no time to appear between cuts), but there's also smoke in the air that wasn't there in the previous shot. (And also had no time to appear between cuts).
Continuity mistake: During the final battle, right after Frost's arm regenerates and he says "It's too late, Blade!", Blade begins swiping his sword at Frost rapidly. You can hear the sound of Blade's sword slicing into Frost's shirt, and even see numerous pieces of fabric from the shirt flying about in the air as Blade shreds off pieces. Yet, for the rest of the scene, Frost's shirt is almost completely undamaged, save for one or two small tears. This makes no sense, as we had just seen and heard Blade slicing off numerous pieces of fabric from the shirt. The pieces seen flying through the air were actually added later using computer effects to make the scene look more dramatic, thus creating the continuity problem.
Continuity mistake: When Whistler is giving Blade the injection, watch the vial. It starts full, then in a close up, you can see the serum level drop. Then the camera goes to a wide shot, and the fluid level is almost full and dropping, The next close up, and the serum level falls to completely empty.
Continuity mistake: There is a scene where Blade and Frost are having a discussion sitting across from one another. The shot changes back and forth from Blade to Frost as they speak. On the table you can see a pack of cigarettes next to frost that changes position in every shot and even disappears entirely in one of the shots.
Continuity mistake: When Blade throws the darts full of EDTA into Frost at the end of the movie, they all just sit there in Frost's flesh, not pumping the blue fluid into him (this is especially evident after Blade kicks the final one into Frost's face). This is a blooper in and of itself, because as we saw earlier (as Blade fought two vampire guards and killed them with the same darts), the darts quickly pump the fluid out upon impact. What's more, all the darts are suddenly completely empty in the zoom-out shot of Frost's body bubbling and expanding from the reaction to the EDTA.
Continuity mistake: When Blade is escaping from the police, after he jumps across the building he uses a red door as a sheild. The police shoot the red door and it splinters. After the doctor pops his shoulder back in, the cops shoot the door again but there are no visible marks from the bullets before and instead of a wooden door it's now metal.
Chosen answer: It would seem Deacon has gathered a lot of strength around himself, in followers of "young" vampires like himself. After he kills Gitano he just abducts all the vampire elders, showing his followers are a lot stronger than the elders are. So they probably couldn't have killed him even if they wanted to, not unless they want to unleash a war. They thought his pursuit of the vampire god was totally pointless, so they let him waste his time and were probably trying to find a way to get rid of him.
lionhead