In the UK, the film (and the cartoon show, as well) is called "Teenage Mutant Hero Turtles." The name was changed because it was believed that British children become overexcited when they hear, or see anything to do with ninjas.

Ernie Reyes Jr., who played Keno in the second movie, was the martial arts double for Donatello.

All reporters in the movie seem to have to name of a month, i.e. April, June.

At one point in the movie Shredder scolds his bald henchman, and right after that, the bald guy curses saying, "kuso." That's about the equivalent of saying sh*t in Japanese.

The four actors playing the Turtles also had cameo appearances in the movie without their costumes: Tilden (Donatello) was the Foot messenger that says "We've been looking for you, Miss O'Neil". Pais (Raphael) is the passenger in the taxi cab that says "What the heck was that?" Sisti (Michelangelo) is the pizza delivery man that can't find the Turtle's address. Foreman (Leonardo) plays a gang member in the warehouse when Casey Jones defeats Tatsu.

Because Michelangelo has a pair of nunchaku, BBFC policy at the time of the original release in 1990, was to edit out scenes involving the use of chain sticks because it was feared they could be imitated, so the film was cut for this reason. These cuts were rescinded by the BBFC for its recent re-release in cinemas.

One of the street punks tells the police chief to check out the "East" Warehouse out on "Lairdman" Island. This is a tribute to Kevin Eastman and Peter Laird, the creators of the TMNT.

Skeet Ulrich, from the original Scream movie, got one of his very first on-screen roles with this movie. He can be seen playing an uncredited thug to the left of the kid who tells the cops to check out the warehouse.

Most of the boxes in the warehouse hideout have the "Mirage" logo on them, a nod to Mirage Comics, the publisher of the original TMNT comic book.