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Dr. Wilson: [To House.] Some doctors have the messiah complex – they need to save the world. You have a Rubik's complex – you need to solve the puzzle.

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During a guest appearance on The Tonight Show on 16 November 2005, Laurie revealed that he took the highly-addictive painkiller Vicodin in order to get into character for his role as Dr. House. See more...

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Detox (season 1, episode 11)

Mistake Continuity: As Cuddy is making the deal with House, how much time off from Clinic duty for a week off his vicodin, while the camera is behind Cuddy you can see there is bright sunshine on House's head. The shot switches to a camera behind House and now his head is shaded.

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