Question: I am curious why Helen was killed when the doctor was the target. Harrison Ford (the doctor) said he found out why Helen was killed - he said on the phone and stated the reason was "they were after me." So - someone goes to kill him and kills his wife instead? Was it to frame him and if so, wouldn't it have been easier to kill him instead?
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Answer: The one-armed man was there to kill Richard, but Helen was the one at home. Sending him to prison would have discredited him enough to satisfy the pharmaceutical company.
Captain Defenestrator
And don't forget, Kimble wasn't just sentenced to prison - he was sentenced to death. Nichols probably thought he'd seen the last of him.