Question: [Minor spoiler] I'm curious, because I can't remember 100%. Ryan Reynolds as Wade is very similar to Deadpool in the comics. The bad guy in the final fight, however, is nothing like the comic Deadpool, and I'm fairly sure that while it's of course strongly implied that he's the product of experiments on Wade, it's never explicitly stated. Stryker makes a reference to a "dead pool", and Wolverine says something like "Wade, is that you?" (with no answer), but as far as I can remember there's no concrete connection between Ryan Reynolds' character at the start and that final bad guy beyond implication/our assumption. I'm largely curious because there was talk of a Deadpool spinoff with Ryan Reynolds, and with the changes to the character, plus the events at the end of the film, that might be difficult, so I'm wondering if they left a deliberate loophole so if they make a Deadpool film they can just say "no, that wasn't him - everyone just assumed it was. The real Deadpool was off somewhere else". Make sense?
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Chosen answer: If you stayed past the credits one of the possible bonus scenes was Weapon XI's hand reaching out from the rubble of the nuclear complex to touch his severed head, whereupon the head comes to life and makes a brief hushing sound before the scene fades to black; breaking the fourth wall like the Deadpool comics. So he's not dead, and his mouth is unsealed - chances are if a Deadpool film is made they'll be able to use the excuse of his healing factor to make some changes. Although yes, it's not explicitly stated in the film that Weapon XI is Wade, just heavily implied and assumed by several characters.