Mary Jane Watson: What's happened to you?
Peter Parker: I don't know. But I have to stop it.
During the fight scene with Sandman in the armor car, the Terminal Tower can be seen in the background, which is a landmark in Cleveland, Ohio (where the scene was shot), not in New York city.
While taunting Spider-Man about Mary Jane in the final battle scene, Venom says, "How's that sound, tiger?" He says the same line in the 1990s Spider-Man animated series.