Continuity mistake: When Santana is trying to open the locker, after he enters the third "click", he talks with Johns and looks at him, putting his back to the locker. In one shot Santana is near the locker, but in the long shot, he is further from it.
Continuity mistake: When Santana is going to open the bloody written locker, he takes the key off his neck, but when he puts the key in the keyhole, it's around his neck again. Some moments later, when he is talking with Johns, the key is off his neck again.
Character mistake: In Pitch Black they established the system they crashed in (M-344/G) had 3 stars. Jack stated it when the 2nd sunrise started, and the solar system model also had 3 stars. In this film when Boss Johns starts asking about M-344/G he's told it is a backwater system with 2 suns and 1 habitable planet.