Continuity: When Rex strangles Pluto, Dina, who was right by Pluto's side in the close-up, disappears in the side-on shot.

Audio problem: During the scene where the girl is talking to Pluto in the club, he tells her that he was the one that saved her father's life. She responds with "Thanks Dad" but her lips don't even move.

Factual error: During the fight scene on the moon outside Pluto Nash's hideout, dust can be seen floating around when kicked up. In the absence of an atmosphere and in low gravity, dust wouldnt form in clouds, but would just fly up and fall like water.