Continuity mistake: In the beginning of Part 3, Ryan Reynolds is on a deserted two-lane highway asking Hope Davis for help. She refuses to help, begins to turn and walk away down the double-yellow center lines of the road. In the next shot, we see her finishing the turn and walking on the edge of the road, by the white line (facing traffic). Immediately after, she is shown on the right side of the road, on the other white line (walking with traffic). (01:14:15)
Continuity mistake: When Frylock is watching New Jersey getting destroyed by the Insane-O-Flex, look for a building to the left through the Ferris Wheel. When Meatwad transforms into a building, the fires briefly stop, then turn on again.
Continuity mistake: The two protagonists are having a conversation at a long table. Michael Caine sends a bottle of wine rolling across the table. Jude Law opens it and pours. The bottle label now faces him. After Caine says the line "I've never heard of an Italian called Tindale", Milo hasn't moved but the bottle faces the camera now. There's another subtle change in angle and level of the liquid a bit later when Caine says that his wife would get the "Tindelini" last name. (00:09:20)