Trivia: Kathleen Turner almost didn't take the lead role because she finds gory movies too disturbing. At first she said she would only be in the film if the violence was portrayed cartoonishly and unrealistically. Director John Waters convinced her that the violence needed to be portrayed very realistically, because that would be even funnier... the absurdity of so much twisted violence coming out of a seemingly perfect sitcom-style housewife. Turner eventually agreed with Waters and signed on.
Trivia: Director John Waters considers this the best film (and his personal favorite) that he's ever made.
Trivia: The video store you see in this film is director John Waters' actual neighbourhood video store.
Trivia: Director John Waters has a voice-over cameo as the voice of Ted Bundy in the tape that's found.
Trivia: Matthew Lillard plays the titular "Serial Mom's" son. Two years later, he would go on to play one of the serial killers in the famous slasher-satire "Scream."
Trivia: Both Julie Andrews and Susan Sarandon were considered for the titular character.
