Dominic Toretto: It starts with the eyes. She's gotta have those kind of eyes that can look right through the bullshit, to the good in someone. 20% angel,80% devil. Down to earth. Ain't afraid to get a little engine grease under her fingernails.
Gisele Harabo: That doesn't sound anything like me.
Dominic Toretto: It ain't.
Brian O'Conner: This is where my jurisdiction ends.
Dominic Toretto: And this is where mine begins.
Antonio Braga: So, you know each other?
Dominic Toretto: He used to date my sister.
Antonio Braga: You're a lucky man.
Brian O'Conner: How's that?
Antonio Braga: You're still breathing!
Dominic Toretto: Just like old times.
Agent Sophie Trinh: So which car do you want?
Brian O'Conner: All of them.
Answer: No it doesn't ignore 2 Fast 2 Furious, Brian even references it a couple of times. In that movie, Brian was promised a 'clean slate' if he helped them out which presumably gives him the option to rejoin a law enforcement agency. That he chose not to open a garage with Roman is pretty much redundant, Brian simply got a better offer, and as he stated in Fast & Furious with his conversation with Mia, "I'm a good liar".
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