Continuity mistake: As Jack's initial pursuit of the bus begins, you can see although both vehicles are supposed to be traveling north on the 110 freeway, the sun changes position during filming several times. Shining on all sides for several minutes. This lasts up until the moment that Jack boards the bus.
Continuity mistake: When Jack pulls the Jaguar alongside the bus and starts honking, Tuneman's right hand changes its position between shots. First he's got a grip on the vent window, but then all of a sudden his hand rests on the windshield's upper edge. (00:36:45)
Answer: If they had, there might have been the possibility that to get to these routes they would have to go down a different road and depending on which route they take they might have to slow down to make the turn which would likely cause the bus to drop below 50 mph. Better to just keep going straight and keep the bus going. There's also the possibility that had they taken a different route, they would have to deal with a lot of traffic especially if there was traffic stopped at a red light. By using the highway, there'd be no traffic lights and less traffic to deal with.