The Pork Chop Indeterminacy - S1-E15
Character mistake: In his conversation with Missy Sheldon makes it clear that his superior intelligence is a result of a random, mutated gene. Since Missy isn't similarly intelligent she obviously isn't carrying this mutated gene (which would be a billion to one shot anyway) so her offspring wouldn't inherit it. Sheldon would know this - his offspring would carry the mutated gene for superior intelligence, Missy's would not. Anyone knowing enough about genetics to use the term 'randomly mutated gene' understands enough to know that the mutated gene would only be expressed in a direct line from the carrier - Sheldon. Also bear in mind he has a model of the DNA molecule in his living room - it is obviously an interest.
Continuity mistake: Sheldon puts the bag in the bin at the start of the episode so that the handles are facing the ground. When he gets the bag out, the handles are at the top of the bin.
The Hamburger Postulate - S1-E5
Character mistake: When Sheldon knocks on Penny's door to seek advice about the tie on Leonard's doorknob, he does not use his typical triple knock. (00:07:43)
First time he knocks 3 times is in Episode 2 of Season 1. First time knocking 3 times followed by saying the name is episode 10 of Season 1. The ritual of 3 knocks and 3 times saying the name and then stopping is Episode 5 of season 2.
Sheldon knocks three times because he once walked into his parents bedroom and saw his father with another woman. He's been doing the triple knock since he was a teenager.
Yet, he didn't in the show till Season 2. Funny ain't it?
Suggested correction: A one-time lapse in someone's usual behavior does not count as a "character mistake", even in the case of someone given to ritualistic behavior as Sheldon is.
Ah, but in an episode he explains he had developed this particular ritual at age 13 after walking into his parent's bedroom without knocking and seeing his father having sex with another woman. He says he started knocking 3 times since then and would never forget. So its not consistent and a mistake as this is not the only example one can name.
Continuity mistake: In "The Luminous Fish Effect" (S1E04) Sheldon tells Penny he weighs 140 pounds. In "The Porkchop Indeterminacy" (S1E16), he tells his sister he weighs 165. 25lbs difference would be a noticeable change, but he looks the same.
Suggested correction: Lying to Penny but not to his sister, not inconsistent with the characters and his relationships.
Continuity mistake: Raj talks in front of Penny near the beginning of the episode, then picks up dishes, walks toward the kitchen, and just disappears from the set.
Suggested correction: Couple of points here, 1. Raj talking in front of Penny is already listed. 2. Raj doesn't pick the plates up until Penny has left after the Halo game. 3. He then stays in the kitchen area while we see Penny come back and settle down to go to sleep and Leonard and Sheldon go to bed and turn the lights out. Raj then creeps out the apartment and scares Penny.
The Big Bran Hypothesis - S1-E2
Other mistake: Leonard is awoken by the apartment door closing. When he walks into the living room the door is open. (00:08:55)
Suggested correction: He's awoken by a door closing, not necessarily the front door. He could have heard Sheldon closing his door.
The Big Bran Hypothesis - S1-E2
Character mistake: Sheldon does not do his 3x OCD knock on Penny's door.
Suggested correction: That quirk wasn't brought into the series until halfway through the first season. The one-knock Sheldon happened a couple of times before it became the three knock habit.
Suggested correction: Genes can be dormant. Which allows them to skip generations. Therefor Missy's children could actually get the "mutated" gene. This is especially true since Sheldon and Missy are twins. Also, since the episode is about who out of Leonard, Howard or Raj, Sheldon would allow to "mate" with his sister, there is the added "insurance" of getting any smart genes from any of the 3 Lothario's mentioned above.
If you are going to try to argue with a geneticist about genetics, please use the correct terms. Sheldon is not referring to a recessive gene - there is no such thing as a dormant gene - he is speaking of a randomly mutated gene. Those are the words he used. If he had inherited a homozygous recessive karotype - one recessive gene from each of his parents - then somewhere in his family tree there would similarly gifted people, in which case he would use the correct term - a recessive gene. If Missy is a heterozygotic dominant karotype possessing the recessive gene for super-genius and the dominant for ordinary intelligence then mating her with Howard, Raj or Leonard would be a waste of time as their dominant genius gene would prevent the recessive super-genius gene from being expressed in the phenotype of the resulting child. The child would be highly intelligent but not on Sheldon's standards. It doesn't matter if Sheldon does not know any of this as he refers several times to a randomly mutated gene, not a recessive one. Missy does not carry the super-genius gene. The posting is correct.
Sheldon is prone to magical thinking when necessary to preserve his obsessive need to control his environment. He may have simply ignored the flaw in his reasoning, as even the most intelligent humans do when venturing outside their ares of expertise. He may be interested in the science of genetics, but his Ph.D. in physics doesn't qualify him as an expert in that field.