Continuity mistake: In the beginning of the series, Haley's big family is brought up often, implying that she has 3 brothers and 3 sisters. When her mom visits her, Taylor and Quin to announce that she is dying, there is no mention of or visit from any other siblings and Lydia talks about those 3 as if they are her only children.
Continuity mistake: When Lucas is with Keith at the graveyard in 4-10 and Brooke is standing in front of "Peyton's" tombstone, it says she died on March 1, 2006. Keith notes that she died on the day of the shooting. However in this episode Lucas visits Keith's grave where his tombstone says he died in January 2016.
Visible crew/equipment: When Lucas meets Peyton by his tow truck there's a crewmember wearing a green shirt with arms and legs visible next to him.
Visible crew/equipment: The scene where Lucas meets Payton on the side of the road with the tow-truck. Once they are ready to get into the truck you can see equipment in the middle of the road, as Payton starts walking towards Lucas. (00:28:50)
Searching for a Former Clarity - S6-E18
Continuity mistake: In the legendary "a random dog eats Dan's heart" scene, the cooler and its lid keep changing position between shots when they fall on the floor.
4 Years, 6 Months, 2 Days - S5-E1
Continuity mistake: When Hailey finds Nathan asleep on the couch and cleans up his mess she originally has 2 beers and a bottle of tequila, but in the next shot she has beer, tequila and chips.
Everything in Its Right Place - S4-E11
Character mistake: Brooke and Rachel are in the clean teen meeting and they are asked if they want to join. After both saying yes, the clean teen president hands them their shirts but calls Rachel Brooke, and Brooke Rachel. You can see their hair colors and they didn't change spots when she went to get the shirts.